SELECTION OF SNP MARKERS: ANALYZING GAW17 DATA USING DIFFERENT METHODOLOGIES

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Published: Mar 30, 2021
DOI: https://doi.org/10.28951/rbb.v39i1.499

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Mariana Pavan IÓCA
Universidade Federal de São Carlos
Daiane Aparecida ZUANETTI
Universidade Federal de São Carlos

Abstract

The quantity and complexity of generated data due to advances in genetic sequencing technologies has made statistical analysis an essential tool for their correct study and interpretation. However, there is still no agreement about which methodologies are more appropriate for those data, especially for the selection of genetic features that influence a specic phenotype. Genetic data are usually characterized by having a number of variables which is much greater than the number of observations. These variables exhibit little variability and high correlation. These characteristics hinder the application of traditional methodologies for variable selection. In this work (i.) we present dierent methodologies for selecting variables - Random Forest, LASSO and the traditional Stepwise method; (ii.) we apply them to genetic data to select SNP markers that characterize the presence or absence of a disease and (iii.) we compare their performances. Random Forest and Lasso show similar prediction performance, however none of them correctly select the relevant SNPs.

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How to Cite
IÓCA, M. P., & ZUANETTI, D. A. (2021). SELECTION OF SNP MARKERS: ANALYZING GAW17 DATA USING DIFFERENT METHODOLOGIES. Brazilian Journal of Biometrics, 39(1), 71–88. https://doi.org/10.28951/rbb.v39i1.499
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Vol. 39 No. 1 (2021): SPECIAL ISSUE ON BIOSTATISTICS AND BIOMETRY IN THE ERA OF DATA SCIENCE
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Articles
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