A BAYESIAN DESIGN TO TEST DOSE-RESPONSE SEQUENTIAL TRIALS USING ISOTONIC REGRESSION
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Abstract
The present work aims to achieve a dose with a pre-specified toxicity rate in a target population. It proposes, using Bayesian methods and isotonic regression, a sequential design to allow the researchers to update prior information. The theory behind the design is not easily assimilated to non-statisticians. What makes such approach attractive is its reduction to four steps of easy manipulation, without the need of computational effort. Simulation procedures confirm the effectiveness of the proposed methodology.
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SOUZA, E. M. de, CHAVES, L. M., MUNIZ, J. A., & SOUZA, D. J. (2016). A BAYESIAN DESIGN TO TEST DOSE-RESPONSE SEQUENTIAL TRIALS USING ISOTONIC REGRESSION. Brazilian Journal of Biometrics, 34(2), 347–364. Retrieved from http://www.biometria.ufla.br/index.php/BBJ/article/view/145
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